1. the real physical matter of which a person or thing consists

- DNA is the substance of our genes

Definition categories: general, matter, component, constituent, part, portion

2. the choicest or most essential or most vital part of some idea or experience

Similar word(s): center, centre, core, essence, gist, heart, inwardness, kernel, marrow, meat, nub, pith, sum

Definition categories: thought, content

3. the idea that is intended

Similar word(s): meaning

Definition categories: thought, idea

4. material of a particular kind or constitution

- the immune response recognizes invading substances

Definition categories: substance

5. considerable capital (wealth or income)

Similar word(s): means

Definition categories: possession, capital

6. what a communication that is about something is about

Similar word(s): content, message

Definition categories: communication

7. the property of holding together and retaining its shape

Similar word(s): body, consistence, consistency

Definition categories: attribute, property

8. a particular kind or species of matter with uniform properties

- shigella is one of the most toxic substances known to man

Definition categories: general, matter

Sentences with substance as a noun:

- Some textile fabrics have little substance.

- a man of substance

- substance abuse