stopple(noun, verb) noun1. blockage consisting of an object designed to fill a hole tightlySimilar word(s): plug, stopperDefinition categories: man–made, block, blockage, closure, occlusion, stop, stoppage verb1. close or secure with or as if with a stopper- She stoppered the wine bottle- The mothers stoppered their babies' mouths with pacifiersSimilar word(s): stopperDefinition categories: contact, plug, secure