1. causing irritation or annoyance

- nettlesome paperwork

Similar word(s): disagreeable, annoying, bothersome, galling, irritating, pesky, pestering, pestiferous, plaguey, plaguy, teasing, vexatious, vexing

2. easily irritated or annoyed

- not the least nettlesome of his countrymen

Similar word(s): cranky, fractious, irritable, peckish, peevish, pettish, petulant, scratchy, techy, testy, tetchy

Sentences with nettlesome as an adjective:

- My poison ivy rash is very nettlesome.

- The task of proving Fermat’s “last” theorem remains nettlesome.

- Be careful what you say to him; he's a nettlesome fellow.