manacle(noun, verb) noun1. shackle that consists of a metal loop that can be locked around the wrist; usually used in pairsSimilar word(s): cuff, handcuffDefinition categories: man–made, bond, hamper, shackle, trammel verb1. confine or restrain with or as if with manacles or handcuffsSimilar word(s): cuff, handcuffDefinition categories: contact, fetter, shackle